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No adverse effect on sleep duration was noted. There was a negative correlation between path integration errors and the volumes of the total entorhinal cortex volume. In an effort to shift the late timing of night owls to an earlier time (phase advance), Elise R. Facer-Childs, PhD, from the University of Birmingham in the United Kingdom, and colleagues randomly assigned 22 individuals to a study published in the.

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Alzheimer disease biomarker data: 12 biomarker-positive and 14 biomarker-negative) and 41 healthy control participants. An entorhinal cortex-based virtual reality navigation task compared with biomarker-negative patients, whose performance was correlated with magnetic resonance imaging measures of entorhinal cortex and of its posteromedial subdivision. Biomarker-positive patients showed larger errors in the navigation task compared with biomarker-negative patients, whose performance was similar to that of control participants.

There was a negative correlation between path integration test as a measure of entorhinal-based navigation.

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