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Taking Desvenlafaxine with other drugs that make you sleepy or slow your breathing can increase these effects. Ask your doctor before taking Desvenlafaxine with a sleeping pill, narcotic pain medicine, muscle relaxer, or medicine for anxiety or seizures.

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• any other antidepressant;
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• a diuretic or "water pill";
• lithium;
• midazolam;
• imatinib;
• St. John's wort;
• tryptophan (sometimes called L-tryptophan);
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• antifungal medication--itraconazole, ketoconazole, posaconazole, voriconazole;
• heart medication--nicardipine, quinidine;
• hepatitis C medications--boceprevir, telaprevir;
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